Shar-Pei

Shar-PeiShort back, petite body, head larger than body, black nose and dark blue tongue, One of its characteristics is that it is full of wrinkles. Wrinkles generally indicate that people are getting older. So why do Shar-Pei dogs have so many wrinkles?

Researchers at the Autonomous University of Barcelona found that Shar Pei dogs all have mucin hyperplasia, which is hereditary. guided by dissonance. The significance of this research is that it can help Shar-Pei breed better and help improve its health. Mucin hyperplasia in Shar-Pei dogs is caused by the accumulation of hyaluronic acid (one of the important factors in organizing intercellular spaces) in the skin tissue. This accumulation efficiency leads to very high hyaluronic acid concentration in their blood. After cultivating and studying fibroblasts isolated from the skin of Shar-Pei dogs, scientists confirmed that the large amount of hyaluronic acid synthesis is due to a very reduced activity (overexpression) of an enzyme called HAS2. It is one of three enzymes that control acid synthesis in mammals.

Hyaluronic acid is mainly stored in the spaces of various tissue cells, while the hyaluronic acid in Shar-Pei dogs is not broken down. Accumulated in skin tissue and blood vessels, eventually leading to the emergence of mucin hyperplasia. Scientists' research on the fibrous cell structure of Shar-Pei dog skin revealed that an enzyme called HAS2 is the "troublemaker." Scientists are studying how genetic mutations direct this enzyme to be very specific. This research is also of great significance to humans.

So, does the Shar-Pei have many special items? If you are interested in Shar Pei dogs, then get one as soon as possible.



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